Apple is planning a series of new Mac processors for introduction as early as 2021 that are aimed at outperforming Intel's fastest. From a report: Chip engineers at the Cupertino, California-based technology giant are working on several successors to the M1 custom chip, Apple's first Mac main processor that debuted in November. If they live up to expectations, they will significantly outpace the performance of the latest machines running Intel chips, according to people familiar with the matter who asked not to be named because the plans aren't yet public. Apple's M1 chip was unveiled in a new entry-level MacBook Pro laptop, a refreshed Mac mini desktop and across the MacBook Air range. The company's next series of chips, planned for release as early as the spring and later in the fall, are destined to be placed across upgraded versions of the MacBook Pro, both entry-level and high-end iMac desktops, and later a new Mac Pro workstation, the people said. [...] The current M1 chip inherits a mobile-centric design built around four high-performance processing cores to accelerate tasks like video editing and four power-saving cores that can handle less intensive jobs like web browsing. For its next generation chip targeting MacBook Pro and iMac models, Apple is working on designs with as many as 16 power cores and four efficiency cores, the people said. While that component is in development, Apple could choose to first release variations with only eight or 12 of the high-performance cores enabled depending on production, they said. Chipmakers are often forced to offer some models with lower specifications than they originally intended because of problems that emerge during fabrication. For higher-end desktop computers, planned for later in 2021 and a new half-sized Mac Pro planned to launch by 2022, Apple is testing a chip design with as many as 32 high-performance cores.

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Cyberpunk 2077, one of the most highly anticipated video games of the past decade, has already been delayed three times. Employees at CD Projekt Red, the Polish studio behind the game, have reportedly been required to work long hours, including six-day weeks, for more than a year. The practice is called "crunch" in the video game industry, and it is sadly all too common. From a report: It's also something that the leadership at CD Projekt Red said wasn't going to happen to the people making Cyberpunk 2077. Video game developers rarely speak openly with the press about their labor practices, but that's just what CD Projekt co-founder Marcin Iwinski did in May 2019. In a conversation with Kotaku, he said that his company thought of itself as more humane than its competitors. While long hours would be permitted for those interested in working them, crunch would not be made "mandatory." He called it a "non-obligatory crunch policy" and said it was something to be proud of. [...] Shortly thereafter, signs began to emerge that the Cyberpunk 2077 project was in trouble. In January 2020, CD Projekt announced the game's first delay. The release date was moved from April to September. The multiplayer component was also pushed into at least 2022. "We need more time to finish playtesting, fixing and polishing," said IwiÅski and head of studio Adam Badowski. That same day, during a public call with investors, CD Projekt revealed that crunch would ultimately be needed to get the game done on time. It would also be mandatory for at least some employees. "Is the development team required to put in crunch hours?" asked an investor, to which CD Projekt CEO Adam KiciÅski answered, "To some degree, yes, to be honest." [...] In September, Bloomberg reiterated what CD Projekt's leaders said to investors months before. A leaked email mandated six-day work weeks. Crunch had become a requirement, and according to anonymous employees, some developers had been working nights and weekends "for more than a year." In other words, delays do not mean relief for workers. Oftentimes, it simply means working at the same exhausting pace for additional weeks or months.

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"NASA's twin Voyager probes keep making discoveries in interstellar space," reports Space.com The Voyager mission has detected a new type of "electron burst," which will provide insights into the mechanisms of flaring stars, a new study reports. The bursts occur when cosmic ray electrons — fast-moving particles from far beyond the solar system — are pushed by shock waves generated by solar eruptions. The electrons then accelerate further along cosmic magnetic field lines to incredible speed, study team members said. "The idea that shock waves accelerate particles is not new," corresponding author Don Gurnett, professor emeritus in physics and astronomy at the University of Iowa, said in a statement. "[But] we detected it in a new realm: the interstellar medium, which is much different than in the solar wind, where similar processes have been observed...." Eventually, the magnetic field lines propel the cosmic rays to almost the speed of light — nearly 670 times faster than the solar shock waves that first pushed them. (The shock waves move at roughly 1 million mph, or 1.6 million kph, study team members said.) The article marvels at the fact that the spacecraft are still sending back data regularly from 14 billion miles away, beyond the edge of our solar system, more than 43 years after they left earth. They even detected the original solar shock wave which caused the electron burst "up to a year after the event occurred. "The wait time happened because the spacecraft are so far from the sun."

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Writing for TechRepublic, open source advocate Jack Wallen predicts 2021 will be a year where open source technology dominates the world of big data even more than 2021 (with a big role predicted for SUSE). But he also sees businesses cutting costs by switching to open source solutions — including a big move to Linux on enterprise desktops, thanks to enterprise-ready options now available from System76, Lenovo, and Dell: This will have the added benefit of even more companies jumping into the mix and offering more and more desktops and laptops, all powered by Linux and open source technology. One added bonus for this movement is that System76 will finally gain the recognition they've deserved for so many years. Linux on the desktop would not be where it is today, had it not been for their stalwart support for open source technology. Year after year, System76 has proved that high-quality, business-class systems, powered by Linux, can be produced at a level befitting the enterprise. That success within the realm of business will start trickling down to consumers. As more and more people start using Linux at their place of business, they'll begin seeing the benefits of the open source operating system and desire to adopt it for their home computers. I suspect that by the end of 2021, we'll see Linux desktop market share to finally break the 10% bubble. It may not sound like much, but given how Linux has hovered around 2% and maxed out at 5%, that 10% figure is like a dream come true. That's only the tip of the iceberg. Although Linux will max out at around 10% by the end of the year, it will lead to continued growth over the coming years.

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ZDNet reports: Under the guise of a "cybersecurity exercise," the Kazakhstan government is forcing citizens in its capital of Nur-Sultan (formerly Astana) to install a digital certificate on their devices if they want to access foreign internet services. Once installed, the certificate would allow the government to intercept all HTTPS traffic made from users' devices via a technique called MitM (Man-in-the-Middle). Starting today, December 6, 2020, Kazakh internet service providers (ISPs) such as Beeline, Tele2, and Kcell are redirecting Nur-Sultan-based users to web pages showing instructions on how to install the government's certificate. Earlier this morning, Nur-Sultan residents also received SMS messages informing them of the new rules. Kazakhstan users have told ZDNet today that they are not able to access sites like Google, Twitter, YouTube, Facebook, Instagram, and Netflix without installing the government's root certificate. This is the Kazakh government's third attempt at forcing citizens to install root certificates on their devices after a first attempt in December 2015 and a second attempt in July 2019. Both previous attempts failed after browser makers blacklisted the government's certificates.

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The Verge writes: Maybe you're feeling nostalgic for a classic James Bond film following Sean Connery's death in late October. Or perhaps you're simply feeling a gap given that the next film, No Time to Die, got pushed back to April 2021 or beyond. Either way, you can now binge a sizable selection of the James Bond collection completely for free (with ads) from YouTube, Peacock (with its free subscription), and PlutoTV... You can also find most of the films on Hulu and Amazon Prime this month, though you'd have to pay for those subscriptions, and Netflix has Casino Royale, Quantum of Solace, and three Pierce Brosnan flicks including GoldenEye — newly relevant now that the famed Arecibo Observatory, which gets destroyed in the film, has also collapsed in real life.

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"People taking a stroll on Sunday morning stumbled upon another mysterious monolith," reports Insider.com. "This one was found in a northern province of the Netherlands." The monolith was covered in ice and surrounded by a small pool of water, according to local reports. The hikers told the Dutch paper Algemeen Dagblad that they're not sure how the monolith got there. They said they found no footprints around it that would indicate someone placed it there intentionally. And that monolith that disappeared in Atascadero, California has not-so-mysteriously re-appeared, as a group of three local artists takes credit for both creating the original and for successfully retrieving it to restore it to its former glory. "After learning of the second monolith, Travis Kenney had a thought," writes the relationship site Your Tango. "There were three monoliths in 2001: A Space Odyssey. Why not build the third themselves and make the triad complete...?" "It was meant to be something fun, a change of pace from the kind of conversations 2020 has been plagued with — so much negativity and separation among the people in our country." All the thanks these men really needed was delivered in the positive energy that quickly took hold of their home town. The presence of this now internationally followed mysterious object brought with it an uplifting local pride, as well as a sense of childlike wonder... The monolith's creators quietly made the hike back up to observe people's reactions throughout the day. When they arrived at the top each time, they found themselves soaking in the glow of the many smiles they encountered on faces of visitors. some of whom drove for hours to see the shining obelisk for themselves... While you may think of these monoliths as another square on your 2020 bingo card, it's worth noting that the purpose of the monoliths in 2001: A Space Odyssey was to further the advancement of intelligent life. Cynics can say that sounds cheesy, but for the sake of full disclosure, I know McKenzie personally and can affirm without doubt or irony that they wanted nothing more than to offer their fellow humans some joyful light in these dark times. "There was no esoteric agenda," said McKenzie. "Our topline," added Jared Riddle, "Let's get outside and laugh." 70 miles away yet-another monolith "was discovered by campers on Saturday in San Luis Obispo County in Los Padres National Forest," reports a California newspaper. "We were super happy that someone/group went to all that work," Matt Carver wrote in a Facebook message to The Tribune. "It really did make our day to find it! I think we had huge smiles on our faces for the rest of the ride home." The second monolith resembles the monolith in Atascadero, but the structure's top features "CAUTION" written in red and a picture of a UFO beaming in a human. But wait! Insider.com reports that another mysterious monolith has appeared in Pittsburgh — "intentionally placed outside a candy shop by an owner who was trying to attract attention to his small business." Christopher Beers, owner of Grandpa Joe's Candy Shop, asked a friend to make the 10-foot-tall structure and placed it outside his store as a marketing ploy. Grandpa Joe's Candy Shop shared the news using a 30-minute video on Facebook. In a Facebook post on Friday, the shop said: "Come see the Monolith before it mysteriously disappears!" Within one day someone did in fact steal the monolith, reports the Pittsburgh Tribune-Review. But Grandpa Joe's owner Beers whipped up another one to replace it. "This one is much heavier and bolted into the ground. That's not a challenge. That's just a statement." Beers said he didn't report the theft to police because they have more important things to deal with... "That's not the story," Beers said of the theft. "The story is I built something fun and made people laugh and we put Pittsburgh on the map. I'm not worried about whoever took it." Beers said the new monolith will stay up for a couple a days before "it'll mysteriously disappear just like all the others." Business Insider reports that monolith jokes have now also appeared in tweets from a wide variety of brands, including Walmart, Southwest Airlines, Ocean Spray, McDonald's, Steak-umm, and MoonPie. And meanwhile, the headline at one Denver news site reports that "Monolith mania comes to Colorado as local businesses report structures 'appearing' outside shops," citing the arrival of a monolith outside McDevitt Taco Supply and on the patio of Morrison Holiday Bar.

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"People taking a stroll on Sunday morning stumbled upon another mysterious monolith," reports Insider.com. "This one was found in a northern province of the Netherlands." The monolith was covered in ice and surrounded by a small pool of water, according to local reports. The hikers told the Dutch paper Algemeen Dagblad that they're not sure how the monolith got there. They said they found no footprints around it that would indicate someone placed it there intentionally. And that monolith that disappeared in Atascadero, California has not-so-mysteriously re-appeared, as a group of three local artists takes credit for both creating the original and for successfully retrieving it to restore it to its former glory. "After learning of the second monolith, Travis Kenney had a thought," writes the relationship site Your Tango. "There were three monoliths in 2001: A Space Odyssey. Why not build the third themselves and make the triad complete...?" "It was meant to be something fun, a change of pace from the kind of conversations 2020 has been plagued with — so much negativity and separation among the people in our country." All the thanks these men really needed was delivered in the positive energy that quickly took hold of their home town. The presence of this now internationally followed mysterious object brought with it an uplifting local pride, as well as a sense of childlike wonder... The monolith's creators quietly made the hike back up to observe people's reactions throughout the day. When they arrived at the top each time, they found themselves soaking in the glow of the many smiles they encountered on faces of visitors. some of whom drove for hours to see the shining obelisk for themselves... While you may think of these monoliths as another square on your 2020 bingo card, it's worth noting that the purpose of the monoliths in 2001: A Space Odyssey was to further the advancement of intelligent life. Cynics can say that sounds cheesy, but for the sake of full disclosure, I know McKenzie personally and can affirm without doubt or irony that they wanted nothing more than to offer their fellow humans some joyful light in these dark times. "There was no esoteric agenda," said McKenzie. "Our topline," added Jared Riddle, "Let's get outside and laugh." 70 miles away yet-another monolith "was discovered by campers on Saturday in San Luis Obispo County in Los Padres National Forest," reports a California newspaper. "We were super happy that someone/group went to all that work," Matt Carver wrote in a Facebook message to The Tribune. "It really did make our day to find it! I think we had huge smiles on our faces for the rest of the ride home." The second monolith resembles the monolith in Atascadero, but the structure's top features "CAUTION" written in red and a picture of a UFO beaming in a human. But wait! Insider.com reports that another mysterious monolith has appeared in Pittsburgh — "intentionally placed outside a candy shop by an owner who was trying to attract attention to his small business." Christopher Beers, owner of Grandpa Joe's Candy Shop, asked a friend to make the 10-foot-tall structure and placed it outside his store as a marketing ploy. Grandpa Joe's Candy Shop shared the news using a 30-minute video on Facebook. In a Facebook post on Friday, the shop said: "Come see the Monolith before it mysteriously disappears!" Within one day someone did in fact steal the monolith, reports the Pittsburgh Tribune-Review. But Grandpa Joe's owner Beers whipped up another one to replace it. "This one is much heavier and bolted into the ground. That's not a challenge. That's just a statement." Beers said he didn't report the theft to police because they have more important things to deal with... "That's not the story," Beers said of the theft. "The story is I built something fun and made people laugh and we put Pittsburgh on the map. I'm not worried about whoever took it." Beers said the new monolith will stay up for a couple a days before "it'll mysteriously disappear just like all the others." Business Insider reports that monolith jokes have now also appeared in tweets from a wide variety of brands, including Walmart, Southwest Airlines, Ocean Spray, McDonald's, Steak-umm, and MoonPie. And meanwhile, the headline at one Denver news site reports that "Monolith mania comes to Colorado as local businesses report structures 'appearing' outside shops," citing the arrival of a monolith outside McDevitt Taco Supply and on the patio of Morrison Holiday Bar.

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There's a zany twist at the end, because "This year more than ever, we felt that it was important to give people a little lift, to remind them that while we are facing a lot of challenges, there are many ways we can connect, be productive and enjoy the time we have at home," Microsoft's VP of brand, advertising, and research told Adweek. But long-time Slashdot reader theodp shares a different opinion: While Adweek finds it "heartwarming", Windows Central's Sean Endicott writes that Microsoft's "Find Your Joy" holiday ad "just left me feeling sad." After lock-downed family members immersed in Microsoft Halo, Teams, Minecraft, and Flight Simulator ignore the family dog, the pooch drifts off to sleep and dreams about being able to use the Microsoft products with fellow canines, including fetching a live grenade in Halo. The ad concludes with the line "This holiday, find your joy." Endicott does not approve: "I expected the ad to end with one of the people playing with the dog or at least cuddling it as it fell asleep. So much for that... Maybe this fictional family does that after the ad finishes, but Microsoft doesn't show it. And that's a real bummer." Adweek points out that in Minecraft's Marketplace, Microsoft is also giving away a free "dogtopia" inspired by the ad (including bacon rollercoasters), while the vintage airplane will appear in Microsoft Flight Simulator, and custom backgrounds from the ad will be made available in Microsoft Teams. Because this year more than ever it's important to give people a little lift to remind them that while we're facing a lot of challenges there's many ways we can connect, be productive and enjoy the time we have at home...

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"We recommend that you discuss this situation with us in the chat," one caller warned, "or the problems with your network will never end." ZDNet reports: In attempts to put pressure on victims, some ransomware gangs are now cold-calling victims on their phones if they suspect that a hacked company might try to restore from backups and avoid paying ransom demands. "We've seen this trend since at least August-September," Evgueni Erchov, Director of IR & Cyber Threat Intelligence at Arete Incident Response, told ZDNet on Friday... "We think it's the same outsourced call center group that is working for all the [ransomware gangs] as the templates and scripts are basically the same across the variants," Bill Siegel, CEO and co-founder of cyber-security firm Coveware, told ZDNet in an email. Arete IR and Emsisoft said they've also seen scripted templates in phone calls received by their customers. The use of phone calls is another escalation in the tactics used by ransomware gangs to put pressure on victims to pay ransom demands after they've encrypted corporate networks. Previous tactics included the use of ransom demands that double in value if victims don't pay during an allotted time, threats to notify journalists about the victim company's breach, or threats to leak sensitive documents on so-called "leak sites" if companies don't pay.

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Engadget reports: The Wall Street Journal has learned that Google is considering "severe penalties" against internet giant IAC (InterActive Corp) over allegedly deceptive practices in its Chrome extensions. The browser extras reportedly promise features that never materialize, point users toward additional ads, or even trick users into installing them. A Google audit reportedly found that some of IAC's voting ads not only didn't take users to voter info, but installed the Ask.com toolbar and changed users' default home pages. IAC kept running those ads even after Google told the company to stop. The full range of potential punishments isn't clear, but Google is considering banning them, according to WSJ sources and leaked documents

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All the videos have now appeared online for the talks at this year's virtual EmacsConf 2020, "the conference about the joy of Emacs, Emacs Lisp, and memorizing key sequences." And among them are an appearance by 67-year-old Richard Stallman, reminding the audience he'd created the first Emacs editor in 1976 "with some help from Guy Steele," then created GNU Emacs in 1984. Stallman was there to tell the history of the GNU Emacs Lisp Package Archive (and the licensing issues involved) — and how it's ultimately led to the creation of the NonGNU ELPA. "The fundamental plan of NonGNU ELPA is that we won't ask for copyright assignments for those packages, so we won't be able to put them into core Emacs, at least not easily — but we will have some control over how we distribute them. We can put any package into NonGNU ELPA as long as its free software. "If we like it, we can set up that way for users to get it. We can put the package in exactly as it is, if there's no problem at all with it. We can make an arrangement with the package's developers to work on it with us and maintain it directly for distribution by NonGNU ELPA. But if they are not interested, we can put it in ourselves, and if we need to make any changes we can do so. So NonGNU ELPA is not meant to be just a way that others can distribute their packages. Its meant at least in a minimal, technical sense to work with GNU Emacs, and we will make changes if necessary so that it works smoothly with GNU Emacs... "The idea is to have a single Git repository where you can download various packages, but they won't be maintained there. Each of those packages will be copied automatically from some other place, probably some other people have the right access to work on it. This way we can avoid giving a gigantic number of people access to it. "So far NonGNU ELPA is just a plan. We need people to implement the plan, so if you'd like to help, please write to me. I think this is a very important step for progress, and it's got to be implemented. Thanks, and happy hacking." Stallman provided a status update on NonGNU ELPA as part of the 46-minute Q&A that followed. "The creation of it has started. There's an archive and you can download packages. There's a repository to put it in... Still working out the procedures, how to make the arrangements with developers, etc." But he also answered questions on other topics. Some highlights: Q: Which distro of GNU/Linux do you use? guix? or something else? RMS: Trisquel. Q: If you knew that you would get hit by a bus tomorrow, say because of a fortune-teller, what would you leave behind in terms of advice for stewardship of Emacs and its future? RMS: Focus on keeping the community strong in defending freedom. If given the choice to have more people developing the software or defending the software, choose the latter. Guard your soul carefully... :P Q: Would you mind sharing your Emacs configuration files? RMS: Configuration files are personal and will not be shared.

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The Washington Post tells the remarkable story of how both Moderna's vaccine and the Pfizer/BioNTech vaccine relied on a specially designed spike protein partially created by America's Vaccine Research Center — along with messenger RNA, "a technology never before harnessed in an approved vaccine." And also decades of path-breaking research: If, as expected in the next few weeks, regulators give those vaccines the green light, the technology and the precision approach to vaccine design could turn out to be the pandemic's silver linings: scientific breakthroughs that could begin to change the trajectory of the virus this winter and also pave the way for highly effective vaccines and treatments for other diseases. Vaccine development typically takes years, even decades. The progress of the last 11 months shifts the paradigm for what's possible, creating a new model for vaccine development and a toolset for a world that will have to fight more never-before-seen viruses in years to come. But the pandemic wasn't a sudden eureka moment — it was a catalyst that helped ignite lines of research that had been moving forward for years, far outside the spotlight of a global crisis... Long before the pandemic, [Vaccine Research Center deputy director Barney] Graham worked with colleagues there and in academia to create a particularly accurate 3-D version of the spiky proteins that protrude from the surface of coronaviruses — an innovation that was rejected for publication by scientific journals five times because reviewers questioned its relevance. His laboratory partnered with one of the companies, Moderna, working to develop a fast and flexible vaccine technology, in the hope that science would be ready to respond when a pandemic appeared. "People hear about [vaccine progress] and think someone just thought about it that night. The amount of work — it's really a beautiful story of fundamental basic research,", said Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases [of which the center is an intramural division]... The leading coronavirus vaccine candidates in the United States began their development not in January when a mysterious pneumonia emerged in Wuhan, China, but decades ago — with starts and stops along the way.... Unlike fields that were sparked by a single powerful insight, [Ugur Sahin, chief executive of BioNTech] said that the recent success of messenger RNA vaccines is a story of countless improvements that turned an alluring biological idea into a beneficial technology. "This is a field which benefited from hundreds of inventions," said Sahin, who noted that when he started BioNTech in 2008, he cautioned investors that the technology would not yield a product for at least a decade. He kept his word: Until the coronavirus sped things along, BioNTech projected the launch of its first commercial project in 2023... On Jan. 13, Moderna RNA scientist Melissa Moore came into work and found her team already busy translating the stabilized spike protein into their platform. The company could start making the vaccine almost right away because of its experience manufacturing experimental cancer vaccines, which involves taking tumor samples and developing personalized vaccines in 45 days. The Post tries to convey how meaningful this moment is for the scientists involved. Years ago one BioNTech scientist had told their spouse, "I just want to live long enough that I can help the RNA go to the patient. I want to see...at least one person would be helped with this treatment." And when the Vaccine Research Center's deputy director finally learned how effective the Pfizer/BioNTech vaccine was, "I just let it all go. "I was sobbing, I guess, is the term."

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The Verge reports that a power component failed on the Orion deep-space crew capsule that NASA hopes to launch (unmanned) from its Space Launch System (or SLS) in late 2021, in a mission called Artemis 1. The problem? It's buried deep within one of the spacecraft's power/data units (or PDUs) within the adapter that connects the capsule to its power/propulsion trunk "service module," so there's no easy way to fix it: As many as nine months would be needed to take the vehicle apart and put it back together again, in addition to three months for subsequent testing, according to the presentation. Lockheed has another option, but it's never been done before and may carry extra risks, Lockheed Martin engineers acknowledge in their presentation. To do it, engineers would have to tunnel through the adapter's exterior by removing some of the outer panels of the adapter to get to the PDU. The panels weren't designed to be removed this way, but this scenario may only take up to four months to complete if engineers figure out a way to do it. A third option is that Lockheed Martin and NASA could fly the Orion capsule as is. The PDU failed in such a way that it lost redundancy within the unit, so it can still function. But at a risk-averse agency like NASA, flying a vehicle without a backup plan is not exactly an attractive option... If engineers choose to remove Orion from its service module, the capsule's first flight on the SLS may be delayed past its current date of November 2021. But the SLS has experienced its own set of delays: it was supposed to fly for the first time in 2017 but hasn't done so yet. It's not clear if the SLS itself will make the November 2021 flight date either; a key test of the rocket coming up at the end of the year has been pushed back, with no new target date set. So it's possible that Lockheed Martin and NASA can fix Orion before the SLS is ready to fly. Any further delays to Artemis I add uncertainty to NASA's lunar landing timeline. NASA is hoping to land astronauts on the Moon by 2024, though many experts are skeptical that such a mission can be pulled off in time. Artemis I is vulnerable to other possible delays, but the component failure adds one more level of uncertainty to when the Orion and SLS combo will get off the ground.

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Long-time Slashdot reader sixoh1 shares "an interesting spin on biotechnology tools that we've been seeing explode lately like Crisper-CAS and mRNA." Ars Technica writes: This is in no way a route to a practical therapy, but it does provide a fantastic window into what we can accomplish by manipulating biology. The whole effort described in the new paper is focused on a simple idea: if you figure out how to wreck one of the virus's key proteins, it won't be able to infect anything. And, conveniently, our cells have a system for destroying proteins, since that's often a useful thing to do... This system relies on a small protein called "ubiquitin." When a protein is to be targeted for destruction, enzymes called ubiquitin ligases chemically link a chain of ubiquitins to it. These serve as a tag that is recognized by enzymes that digest any proteins with ubiquitin attached to them. So, the idea behind the new work is to identify a key viral protein and figure out how to attach ubiquitin to it... Unfortunately, there are no proteins that attach ubiquitin to the viral spike protein. Or, rather, there were no proteins that fit that description. But a team at Harvard has now produced one. They fed atomic-level details of the proteins' structure into software that finds the most energetically-favored interactions between proteins, simulated mutations, and eventually engineered the most promising ones to test their efficacy, ultimately cutting the presence of the viral spike protein in tested cells by 60 percent. Ars Technica ultimately calls it "A mildly insane idea for disabling the coronavirus," though "Unfortunately, it's also likely to be absolutely useless... this is likely to be a non-starter, especially given that there are promising vaccines and many other potential therapies ahead of it in the pipeline for safety testing." Yet "while the details of this work aren't really significant, the fact that we've developed all the underlying technology needed for it is worth keeping in mind."

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sciencehabit summarizes a new article from Science magazine: Attention racehorse jockeys: Start fast, but save enough energy for a final kick. That's the ideal strategy to win short-distance horse races, according to the first mathematical model to calculate how horses use up energy in races. The researchers say the approach could be used to identify customized pacing plans that, in theory, would optimize individual horses' chances of winning. The team took advantage of a new GPS tracking tool embedded in French racing saddles. The trackers let fans watch digital images of the horses move across a screen, and they gave the researchers real-time speed and position data. The scientists studied patterns in dozens of races at the Chantilly racetracks north of Paris and developed a model that accounted for winning strategies for three different races: a short one (1300 meters), a medium one (1900 meters), and a slightly longer one (2100 meters), all with different starting points on the same curved track. The model takes into account not just different race distances, but also the size and bend of track curves, and any slopes or friction from the track surface. The results might surprise jockeys who hold horses back early for bursts of energy in the last furlough. Instead, a strong start leads to a better finish, the team found. That doesn't mean those jockeys are wrong, though. Too strong of a start can be devastating as well, leaving the horse 'exhausted by the end,' one of the researchers says. Even so, "We can't truly model performance," argues a veterinarian at the University of Sydney with over 30 years of experience working at horse racetracks. But he also asks Science, "Do we really want to? "For people who love horse racing, the uncertainty provides the excitement, and the actual running of the horses provides the spectacle and the beauty."

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