🤖 AI Summary
この記事は、魔法の Mushrooms の psychedelic ドラッグである Psilocybin が一度摂取することで脳に持続的な変化をもたらす可能性があるという研究結果について報告しています。25mg の Psilocybin の摂取後1ヶ月後にMRIスキャンで、一部の神経束がより密集し強固になったという証拠が見つかりました。この変化は年齢や認知症において逆説的と報告されています。
研究責任者であるロビン・カーハルティ・ハリス教授は、「どのような意味を持つのかまだわからないが、全体としては精神的な改善があった」と述べています。また、脳の「」（混乱度）が最も上がった被験者は、1ヶ月後に深い心理的洞察とより良い福祉を報告したという重要な見出しがあります。
カーハルティ・ハリス教授は、「Psychedelics は神経間の結びつきを再構築する可能性があり、その「柔軟性」が治療効果の背後にあるかもしれない」と述べています。しかし、この研究には被験者が少ないことや DTI による脳接続の視覚化が间接的で限定的であるという課題もあります。
これらの結果は興味深く、魔法の Mushrooms の使用後に持続的な脳構造の変化があるという最初の証拠となりましたが、さらなる研究が必要です。
A small study found that a single 25mg dose of psilocybin produced measurable brain changes that were still visible a month later, along with reported improvements in psychological insight, wellbeing, and mental flexibility. The Guardian reports: Evidence for the changes came from specialized scans that measured the diffusion of water along nerve bundles in the brain. They suggested that some nerve tracts had become denser and more robust after the drug was taken. While the findings are preliminary, the scientists said the opposite was seen in ageing and dementia. "It's remarkable to see potential anatomical brain changes one month after a single dose of any drug," said Prof Robin Carhart-Harris, a neurologist at the University of California, San Francisco, and senior author on the study. "We don't yet know what these changes mean, but we do note that overall, people showed positive psychological changes in this study, including improved wellbeing and mental flexibility."
[...] Writing in Nature Communications, the researchers describe another key finding. Those who had the largest spike in brain entropy after psilocybin were most likely to report deeper psychological insight and better wellbeing a month later, underlining the link between flexible thinking and improved mental health. "It suggests a psychobiological therapeutic action for psilocybin," said Carhart-Harris. Prof Alex Kwan, a neuroscientist at Cornell University in New York, said studies in mice had shown that psychedelics can rewire connections between nerves, a form of "plasticity" that could underlie their therapeutic effects. The big question is whether the same occurs in humans. "This study comes closer than most to addressing that question, by giving evidence of lasting changes in brain structure after psychedelic use," he said. But while the results were "exciting," the study involved a small number of people and DTI provides an indirect and limited view of brain connections, he said.
Read more of this story at Slashdot.
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